SPDP NHS ester

Synonym: 68181-17-9; SPDP; N-Succinimidyl 3-(2-pyridyldithio)propionate; SPDP Crosslinker; 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

CAS Number: 68181-17-9
PubChem CID: 100682

Size

100 mg; 250 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SPDP NHS ester is a heterobifunctional crosslinker capable of reacting with both amine and sulfhydryl groups. It allows for the covalent linking of biomolecules, such as proteins and peptides. This is valuable in drug delivery systems, where it can be used to attach therapeutic agents to targeting molecules. It also finds application in the development of immunoassays and protein modification studies.

Molecular Weight

312.4

Molecular Formula

C₁₂H₁₂N₂O₄S₂

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

S-S disulfide bond

Reactive Group 1

Amine

Form

Solid

Identity

Confirmed by NMR.

Applications

SPDP (succinimidyl 3-(2-pyridyldithio)propionate) NHS ester is commonly used for conjugating proteins and antibodies to a variety of ligands, allowing for the formation of stable thioether bonds. This is essential in the fields of bioconjugation, diagnostics, and therapeutic antibody development.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.