SPDP/Carboxylic acid PEG reagent, SPDP-PEG3-acid, Purity ≥95%

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Cat. No.: X26-09-ZQ405

SPDP/Carboxylic acid PEG reagent, SPDP-PEG3-acid, Purity ≥95%

Synonym: SPDP-PEG3-carboxylic acid; SPDP-polyethylene glycol3-acid; 3-(2-Pyridyldithio)propionate-PEG3-acid; SPDP-triethylene glycol-acid; SPDP-PEG3-carboxyl

CAS Number: 2088570-69-6
PubChem CID: 155896848

SPDP/Carboxylic acid PEG reagent, SPDP-PEG3-acid, Purity ≥95%

Size

100 mg; 250 mg; 500 mg; 1 g

Price

Datasheet

MSDS

Properties

Description

This product is a heterobifunctional polyethylene glycol (PEG) reagent incorporating a pyridyldithiol (SPDP) group and a terminal carboxylic acid. The SPDP group undergoes thiol-disulfide exchange with free sulfhydryls to form a cleavable disulfide bond, whereas the carboxylic acid enables amidation with free amines. The triethylene glycol spacer maintains aqueous solubility during modification procedures.

Molecular Weight

347.5

Molecular Formula

C₁₄H₂₁NO₅S₂

Functional Group 1

SPDP

Functional Group 2

Carboxylic acid

Reactive Group 1

Thiol

Reactive Group 2

Amine

Reactive Group 3

Alcohol

Purity

≥95%

Applications

This product can be used for reversible crosslinking of thiol-containing macromolecules, synthesis of reduction-responsive polymer networks, and surface attachment of ligands in bio-orthogonal conjugation and chemical biology experiments.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.

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