Cat. No.: X24-03-YW0262
Tetra(cyanoethoxymethyl) methane PEG reagent, Tetra(cyanoethoxymethyl) methane, Purity 92%
Synonym: 2465-91-0; Tetra(Cyanoethoxymethyl) methane; 2465-91-0; 3-{3-(2-Cyanoethoxy)-2,2-bis[(2-cyanoethoxy)methyl]propoxy}propanenitrile; 6,6-BIS(4-CYANO-2-OXABUTYL)-4,8-DIOXAUNDECANE-1,11-DINITRILE; 3,3'-((2,2-Bis((2-cyanoethoxy)methyl)propane-1,3-diyl)bis(oxy))dipropanenitrile
- CAS Number: 2465-91-0
- PubChem CID: 258651
Properties
Description
Tetra(cyanoethoxymethyl) methane is a PROTAC linker composed of alkyl chains. It serves as a crucial component in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the connection between the target protein ligand and the E3 ubiquitin ligase ligand. The presence of nitrile groups in the linker allows for versatile chemical modifications, including hydrolysis, reduction, or cyanide ion release, enabling precise control over the linkage and subsequent protein degradation.
Molecular Formula
C17H24N4O4
Functional Group 1
Tetra(cyanoethoxymethyl) methane
Identity
Confirmed by NMR.
Applications
The unique structure of Tetra(cyanoethoxymethyl) methane makes it highly suitable for the construction of PROTAC molecules, a promising class of therapeutic agents for targeted protein degradation. By incorporating this linker into PROTAC designs, researchers can effectively recruit specific proteins for ubiquitination and subsequent proteasomal degradation, leading to the modulation of protein levels within cells. This linker's ability to undergo controlled chemical transformations provides flexibility in PROTAC design and optimization, allowing for the development of potent and selective protein degraders for various biomedical applications, including drug discovery and chemical biology research.
For Research Use Only. Not For
Clinical Use.
