Description
N-(Amino-PEG10)-N-bis(PEG10-azide) serves as a PEG reagent featuring one terminal amine along with two azide groups. The hydrophilic PEG spacer improves solubility in aqueous media. These azide functionalities are capable of reacting with alkyne compounds like BCN and DBCO through click chemistry processes to create stable triazole linkages. Moreover, the amino group reacts readily with carboxylic acids, activated NHS esters, carbonyls (including ketones and aldehydes).
Applications
In the development of polymeric drug carriers, it can be used to control the architecture and properties of the polymers, influencing drug loading and release kinetics. It can also be utilized in the synthesis of dendrimers or hyperbranched polymers for targeted drug delivery. Additionally, it can be employed in the modification of biomaterials to enhance their interaction with cells and tissues.