NHS PEG reagent, Bis-sulfone-PEG12-NHS ester, Purity 90%, Purity 90%

Synonym: 2055105-51-4; Bis-sulfone-PEG12-NHS ester; 2,5-Dioxopyrrolidin-1-yl 1-oxo-1-(4-(3-tosyl-2-(tosylmethyl)propanoyl)phenyl)-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2-azahentetracontan-41-oate

CAS Number: 2055105-51-4
PubChem CID: 123132078

Size

50 mg; 100 mg; 250 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Bis-sulfone-PEG12-NHS Ester acts as a bis-alkylating labeling agent specifically targeting cysteine sulfur atoms from native disulfides. These reagents facilitate bis-alkylation by conjugating thiols derived from two cysteine residues within reduced native disulfide bonds-such as those found in interchain disulfides of antibodies-resulting in covalent rebridging through a three-carbon bridge while preserving the structural integrity of the protein.

Molecular Weight

1197.4

Molecular Formula

C₅₆H₈₀N₂O₂₂S₂

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

Sulfonyl

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

90%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Bis-sulfone-PEG12-NHS ester could find use in bioconjugation reactions and the modification of large biomolecules for specific purposes.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.